Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Abstract In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures were confirmed by physicochemical and spectral characteristics.The DEFY DAMAGE PROTECTIVE SHIELD synthesized compounds were evaluated for their in vitro anti

read more


Numerical analysis of multipurpose shell-tube-heat exchanger withal stylized geometry at different baffle gaps and various flow rates

The effects of changing 90 mm and 110 mm plate spacings and FR factor of 0.9 kg/h, 1.3 kg/h, 1.7 kg/h, 1.9 kg/h on the total heat transfer performance and PD in the new design HX were examined.The results obtained by taking Kitchen into account the change in plate spacing and FR factor of 0.9 kg/h, 1.3 kg/h, 1.7 kg/h and 1.9 kg/h, as well as variab

read more

Canonical quantization of lattice Chern-Simons theory

Abstract We discuss the canonical quantization of U(1) k Chern-Simons theory on a spatial lattice.In addition to the usual local Gauss law constraints, the physical Hilbert space is defined by 1-form gauge constraints implementing the compactness of the U(1) gauge group, and (depending on the Protein Gel details of the spatial lattice) non-local co

read more